Apoptosis plays an important role in embryonic development, hematopoiesis, maturation of immune system, maintenance of cell stability and growth balance of normal tissues and organs, and even aging of the body. Therefore, the research on apoptosis has been widely carried out in clinical and basic fields, and the detection method of apoptotic cells is very important.

FLIVO ® (Fluorescent in vivo) is a powerful non-invasive method to detect the activity of caspase in vivo. NIR-FLIVO 690 tracer is a non cytotoxic, fluorescent inhibitor of caspases, which is optimized for use in the whole living animal. ICT's NIR-FLIVO 690 tracer probe contains the preferred binding sequence for most caspases (Val Ala Asp or VAD).

Next, let's talk about the ImmunoChemistry (ICT) FLIVO probe, which is used for in vivo detection of apoptosis, to help you with high-precision detection.

FLIVO是細(xì)胞滲透性,無毒的caspase抑制劑,可在體內(nèi)檢測(cè)caspase介導(dǎo)的活體動(dòng)物凋亡。

艾美捷ImmunoChemistry（ICT）FLIVO探針系列天冬氨酸蛋白酶(Caspases)活性檢測(cè)試劑盒，及 FLIVO示蹤劑，主要用于細(xì)胞凋亡活體檢測(cè)，助力科研。

FLIVO探針是什么？

FLIVO(FLuorescence in vIVO)探針是細(xì)胞滲透性、無毒性的天冬氨酸蛋白酶(Caspases)熒光抑制劑，FLIVO可以用于檢測(cè)活體動(dòng)物體內(nèi)Caspase介導(dǎo)的細(xì)胞凋亡、焦亡。FLIVO非常敏感，自然發(fā)生的低水平細(xì)胞凋亡也會(huì)被檢測(cè)到。  

艾美捷 FLIVO探針活體凋亡檢測(cè)之FAM-FLIVO®體內(nèi)Poly Caspase檢測(cè)試劑盒：  

1. FAM FLIVO In vivo Poly Caspase Assay * * * Green carboxyl fluorescein (# 980, 6T; # 981, 24T)

Samples: living animals, isolated tissues

2. SR-FLIVO In vivo Poly Caspase Assay * * * Red sulfonylrhodamine B (# 982, 6T; # 983, 24T)

Samples: living animals, isolated tissues

艾美捷ICT FLIVO探針活體凋亡檢測(cè)之FLIVO示蹤劑：

9112  NIR-FLIVO 690 Tracer In vivo Assay ***Fluorescent label Dylight690 living animals and tissues in vitro 20T  

9113  NIR-FLIVO 690 Free Dye Control Assay ***Fluorescent label Dylight690 living animals and tissues in vitro 20T

9114  NIR-FLIVO 747 Tracer In vivo Assay ***Fluorescent label Dylight747 Living animals and tissues in vitro 20T

9115  NIR-FLIVO 747 Free Dye Control Assay***熒光標(biāo)簽Dylight747 Fluorescent label Dylight747 Living animals and tissues in vitro 20T  

* 僅供科研使用，不得用于醫(yī)療.

FLIVO探針的活體使用對(duì)藥物測(cè)定研究很有價(jià)值，因?yàn)橥ㄟ^活體動(dòng)物的熒光成像可測(cè)定藥物反應(yīng)性所引起的凋亡水平升高或降低。凋亡水平的升高使得粘附的探針更多，因此熒光強(qiáng)度增加。此外，活體技術(shù)避免了從動(dòng)物上取出細(xì)胞和組織的需要，這會(huì)進(jìn)一步誘導(dǎo)凋亡。