英文名稱    ETV2   

中文名稱    ETS相關(guān)蛋白71抗體   

別    名    ER71; Ets related protein 71; ETS translocation variant 2; Ets variant gene 2; Ets-related protein 71; ETSRP71; ETV2_HUMAN.   

供 應(yīng) 商    遠(yuǎn)慕生物 

研究領(lǐng)域    細(xì)胞生物  發(fā)育生物學(xué)  干細(xì)胞  表觀遺傳學(xué)     

抗體來源    Rabbit   

克隆類型    Polyclonal   

交叉反應(yīng)    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,    

產(chǎn)品應(yīng)用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 ETS相關(guān)蛋白71抗體（石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.   

分 子 量    37kDa   

細(xì)胞定位    細(xì)胞核    

性    狀    Lyophilized or Liquid   

濃    度    1mg/1ml   

免 疫 原    KLH conjugated synthetic peptide derived from Human ETV2/ER71   

亞    型    IgG   

純化方法    affinity purified by Protein A   

儲(chǔ) 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4   

保存條件    Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.   

ETS相關(guān)蛋白71抗體產(chǎn)品介紹    background:

ER71 is a 341 amino acid member of the ETS protein family. Localized to the nucleus, ER71 contains one ETS DNA-binding domain which binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'. The gene encoding ER71 maps to human chromosome 19, which consists of around 63 million bases with over 1,400 genes, making up over 2% of human genomic DNA. Chromosome 19 is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin superfamily members, including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family and Fc?receptors. Key genes for eye color and hair color also map to chromosome 19. Peutz-Jeghers syndrome, spinocerebellar ataxia type 6, the stroke disorder CADASIL, hypercholesterolemia and insulin-dependent diabetes have been linked to chromosome 19. Translocations with chromosome 19 and chromosome 14 can be seen in some lymphoproliferative disorders and typically involve the proto-oncogene BCL3.

Function:
ETV2 is a member of the ETS family of transcription factors. It has been proposed that ETV2 acts downstream of BMP, notch and wnt signalling in blood and vessel specification. ER71 has also shown to be important for Flk1 expression as well as hematopoietic and vascular development.

Subcellular Location:
Nuclear.

Similarity:
Belongs to the ETS family.
Contains 1 ETS DNA-binding domain.

Database links:

Entrez Gene: 2116 Human

Omim: 609358 Human

SwissProt: O00321 Human

Unigene: 194061 Human


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.