英文名稱    Dystrobrevin alpha   

中文名稱    肌營養(yǎng)蛋白α抗體   

別    名    Dystrobrevin alpha; DRP3; DTN; DTNA; Dystrophin related protein 3; FLJ96209; LVNC1; OTTHUMP00000163154; OTTHUMP00000163155; D18S892E; DTN-A; DTNA_HUMAN.   

供應商      遠慕生物  

研究領域    細胞生物  免疫學  神經生物學     

抗體來源    Rabbit   

克隆類型    Polyclonal   

交叉反應    Human, Mouse, Rat, Dog, Pig, Cow, Horse,    

產品應用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500肌營養(yǎng)蛋白α抗體 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.   

分 子 量    63kDa   

細胞定位    細胞漿    

性    狀    Lyophilized or Liquid   

濃    度    1mg/1ml   

免 疫 原    KLH conjugated synthetic peptide derived from human DRP3   

亞    型    IgG   

純化方法    affinity purified by Protein A   

儲 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4   

保存條件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.   

肌營養(yǎng)蛋白α抗體產品介紹    background:

Dystrobrevin alpha belongs to the dystrobrevin subfamily of the dystrophin family. It is a component of the dystrophin associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha and beta dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin alpha may be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. Mutations in Dystrobrevin alpha are associated with left ventricular noncompaction with congenital heart defects.

Function:
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration .

Subunit:
Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL4 or DPYSL5. Interacts with synaptic vesicle protein 2 and SH3A domain of intersectin.

Subcellular Location:
Cytoplasm. Cell projection, growth cone. Note=Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone.

Tissue Specificity:
Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord.

Post-translational modifications:
Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3.