英文名稱    Phospho-DBC1 (Tyr454)   

中文名稱    磷酸化膀胱癌缺失基因1抗體   

別    名    DBC1 (Phospho-Tyr454); DBC1 (Phospho Tyr454); DBC1 (Phospho Y454); DBC 1; DBC.1; DBCCR1; Deleted in bladder cancer chromosome region candidate 1; Deleted in breast cancer 1; Deleted in breast cancer gene 1 protein; FAM5A; KIAA1967; OTTHUMP00000022751; p30 DBC; p30 DBC protein; Protein FAM5A; DBC1_HUMAN; Deleted in bladder cancer protein 1.   

供 應(yīng) 商    遠(yuǎn)慕生物

產(chǎn)品類型    磷酸化抗體    

研究領(lǐng)域    腫瘤     

抗體來源    Rabbit   

克隆類型    Polyclonal   

交叉反應(yīng)    Human, Mouse, Rat,    

產(chǎn)品應(yīng)用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 磷酸化膀胱癌缺失基因1抗體（石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.   

分 子 量    103kDa   

性    狀    Lyophilized or Liquid   

濃    度    1mg/1ml   

免 疫 原    KLH conjugated Synthesised phosphopeptide derived from human DBC1 around the phosphorylation site of Tyr454   

亞    型    IgG   

純化方法    affinity purified by Protein A   

儲(chǔ) 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide   

保存條件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.   

磷酸化膀胱癌缺失基因1抗體產(chǎn)品介紹    background:

The DBC1 (Deleted in breast cancer 1) amino terminus binds directly to the estrogen receptor alpha (ERalpha) hormone-binding domain in a strict ligand-independent manner. It may function in the modulation of ERalpha expression and hormone-independent breast cancer cell survival. It is ubiquitously expressed in normal tissues. DBC1 promotes p53-mediated apoptosis through specific inhibition of SIRT1.

Function:
Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway.