英文名稱    DEDD1    

中文名稱    死亡效應(yīng)結(jié)構(gòu)域蛋白1抗體    

別    名    CASP8IP1; Death effector domain containing; Death effector domain containing protein; Death effector domain containing testicular molecule; DEDD 1; DEDD1; DEDPro 1; DEDPro1; DEFT; FLDED 1; FLDED1; KE 05; KE05; OTTHUMP00000031822.    

供應(yīng)商      遠(yuǎn)慕生物

研究領(lǐng)域    腫瘤  細(xì)胞生物  細(xì)胞凋亡      

抗體來(lái)源    Rabbit    

克隆類型    Polyclonal    

交叉反應(yīng)    Human, Mouse, Rat, Chicken, Pig, Cow,     

產(chǎn)品應(yīng)用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 死亡效應(yīng)結(jié)構(gòu)域蛋白1抗體（石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    35kDa    

細(xì)胞定位    細(xì)胞核 細(xì)胞漿     

性    狀    Lyophilized or Liquid    

濃    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human DEDD1    

亞    型    IgG    

純化方法    affinity purified by Protein A    

儲(chǔ) 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存條件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

死亡效應(yīng)結(jié)構(gòu)域蛋白1抗體產(chǎn)品介紹    background:

This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene.

Function:
A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro.

Subunit:
Interacts with CASP8, CASP10, KRT8, KRT18, CASP3 and FADD. Homodimerizes and heterodimerizes with DEDD2.

Subcellular Location:
Cytoplasm. Nucleus, nucleolus.

Tissue Specificity:
Widely expressed with highest levels in testis.

Post-translational modifications:
Exists predominantly in a mono- or diubiquitinated form.

Similarity:
Contains 1 DED (death effector) domain.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.