英文名稱(chēng)    DRAK1    

中文名稱(chēng)    絲氨/酸/蘇氨/酸蛋白激酶17A/DAP凋亡誘導(dǎo)蛋白激酶1抗體    

別    名    DAP kinase-related apoptosis-inducing protein kinase 1; death-associated protein kinase-related 1; EC 2.7.11.1; Serine / threonine kinase 17a death associated protein kinase related 1; Serine/threonine kinase 17a; Serine/threonine protein kinase 17a; STK17 A; STK17A; ST17A_HUMAN.    

供 應(yīng) 商    遠(yuǎn)慕生物     

研究領(lǐng)域    細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  激酶和磷酸酶      

抗體來(lái)源    Rabbit    

克隆類(lèi)型    Polyclonal    

交叉反應(yīng)    Human, Mouse, Rat, Chicken, Rabbit,     

產(chǎn)品應(yīng)用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 絲氨/酸/蘇氨/酸蛋白激酶17A/DAP凋亡誘導(dǎo)蛋白激酶1抗體（石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    50kDa    

細(xì)胞定位    細(xì)胞核     

性    狀    Lyophilized or Liquid    

濃    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human DRAK1/STK17A    

亞    型    IgG    

純化方法    affinity purified by Protein A    

儲(chǔ) 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存條件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

絲氨/酸/蘇氨/酸蛋白激酶17A/DAP凋亡誘導(dǎo)蛋白激酶1抗體產(chǎn)品介紹    background:

DRAK1 (DAP kinase-related apoptosis-inducing protein kinase 1) is a novel member of the ser/thr protein kinase family, which mediate apoptosis through their catalytic activities. The full-length cDNA encodes a deduced 414-amino acid protein with a molecular mass of 46.56 kD. DRAKs contain an N-terminal kinase domain and a C-terminal regulation domain. DRAK1 messenger RNA appears to be ubiquitously expressed in human tissues. Overexpression of DRAK1 induces apoptosis. It has been shown in vitro that DRAK1 is capable of autophosphorylation and of phosphorylating the myosin light chain as an exogenous substrate, and that the noncatalytic C terminus is crucial for full kinase activity.

Function:
Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species.

Subcellular Location:
Nucleus.

Tissue Specificity:
Highly expressed in placenta. Lower levels in heart, lung, skeletal muscle, kidney and pancreas.

Post-translational modifications:
Autophosphorylated.

Similarity:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.
Contains 1 protein kinase domain.