英文名稱  Anti-DNMBP
中文名稱  動力結(jié)合蛋白DNMBP抗體
別    名  Dnmbp; DNMBP_HUMAN; Dynamin binding protein; Dynamin-binding protein; KIAA1010; Scaffold protein TUBA; TUBA.
公司動力結(jié)合蛋白DNMBP抗體應(yīng)用于醫(yī)學(xué)免疫學(xué)、動物免疫學(xué)、分子生物學(xué)、生物化學(xué)、臨床醫(yī)學(xué)、檢驗醫(yī)學(xué)、動物醫(yī)學(xué)、藥學(xué)、理工、農(nóng)學(xué)、環(huán)境學(xué)等生命科學(xué)密切相關(guān)的專業(yè)。
濃    度  1mg/1ml
規(guī) 格  0.2ml/200μg         
抗體來源  Rabbit 
克隆類型  polyclonal
交叉反應(yīng)  Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep  
產(chǎn)品類型  一抗   
研究領(lǐng)域  腫瘤 細胞生物 免疫學(xué) 
蛋白分子量  predicted molecular weight: 177kDa
性    狀  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human DNMBP
亞    型  IgG
純化方法  affinity purified by Protein A
儲 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產(chǎn)品應(yīng)用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500
（石蠟切片需做抗原修復(fù)）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user. 
保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

動力結(jié)合蛋白DNMBP抗體產(chǎn)品介紹 DNMBP, also known as Scaffold protein TUBA, is a 1,577 amino acid protein that localizes to a variety of locations within the cell, including the cytoplasm, cytoskeleton, cell junction and Golgi apparatus, and contains one BAR domain, one DH domain and six SH3 domains. Expressed in kidney, heart, lung, liver, brain, pancreas and skeletal muscle, Tuba functions as a scaffold protein that links Dynamin with Actin-regulating proteins and is thought to play a role in protein trafficking between the golgi and the cell surface. Two isoforms of Tuba exist due to alternative splicing events. The gene encoding Tuba maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.
Function : Scaffold protein that links dynamin with actin-regulating proteins. May play a role in membrane trafficking between the cell surface and the Golgi (By similarity).
Subunit : Binds DNM1 via its N-terminal SH3 domains. The C-terminal SH3 domain binds a complex containing actin, tubulin, Hsp70 and actin-regulatory proteins, such as ENAH, EVL, WASL, WIRE, CR16, WAVE1 and NAP1L1 (By similarity). Interacts with FASLG.
Subcellular Location : Cytoplasm (By similarity). Golgi apparatus, Golgi stack (By similarity). Cytoplasm, cytoskeleton (By similarity). Cell junction, synapse (By similarity). Note=Localized to synapses and Golgi stacks (By similarity).
Tissue Specificity : Detected in heart, brain, lung, liver, skeletal muscle, kidney and pancreas.
Similarity : Contains 1 BAR domain.
Contains 1 DH (DBL-homology) domain.
Contains 6 SH3 domains.