中文名稱  DNA復(fù)制相關(guān)元件結(jié)合因子抗體
別    名  Ac like transposable element; ALTE; BED type zinc finger domain containing protein 1; DNA replication related element binding factor; dREF homolog; hDREF; KIAA0785; Putative Ac like transposon; Putative Ac-like transposable element; TRAMP; ZBED1; ZBED1_HUMAN; Zinc finger BED domain-containing protein 1; Zinc finger BED type containing 1.       
濃    度  1mg/1ml
規(guī) 格  0.2ml/200μg          
抗體來源  Rabbit  
克隆類型  polyclonal
交叉反應(yīng)  Human, Chicken, Dog, Cow, Horse, Rabbit   
產(chǎn)品類型  一抗    
研究領(lǐng)域  細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 鋅指蛋白 表觀遺傳學(xué)  
蛋白分子量  predicted molecular weight: 78kDa
性    狀  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human DREF/ZBED1
亞    型  IgG
純化方法  affinity purified by Protein A
儲(chǔ) 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產(chǎn)品應(yīng)用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500
（石蠟切片需做抗原修復(fù)）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user.  
保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

DNA復(fù)制相關(guān)元件結(jié)合因子抗體產(chǎn)品介紹 ZBED1 is a 694 amino acid protein that localizes specifically to granular structures within the nucleus. Expressed ubiquitously at low levels and present at higher levels in heart, placenta, spleen and skeletal muscle, ZBED1 is thought to function as a transcription factor that regulates a number of ribosomal protein (RP) encoding genes, thereby playing a role in the cell cycle and in cell proliferation events. ZBED1 contains one BED-type zinc finger and binds specifically to 5'-TGTCG[CT]GA[CT]A-3' DNA regions found in RP promotors. Additionally, ZBED1 binds strongly to the promotor region of Histone H1 (a protein required for the condensation of nucleosomes into higher order structures), subsequently activating H1 transcription.

Function : Binds to 5'-TGTCG[CT]GA[CT]A-3' DNA elements found in the promoter regions of a number of genes related to cell proliferation. Binds to the histone H1 promoter and stimulates transcription. Was first identified as gene weakly similar to Ac transposable elements, but does not code for any transposase activity.

Subunit : Homodimer (Potential).
Subcellular Location : Nucleus. In granular structures.
Tissue Specificity : Ubiquitously expressed at low levels. Expression is highest in skeletal muscle, heart, spleen and placenta.
Similarity : Contains 1 BED-type zinc finger.
Database links : UniProtKB/Swiss-Prot: O96006.1

實(shí)驗(yàn)的用途：
1）WB：Western Blotting 免疫印跡
2）IH：Immunohistochemistry 免疫組化
3）IH(P)：Immunohistochemistry Parraffin sections 免疫組化(石蠟)
4）IH(F)：Immunohistochemistry Frozen sections 免疫組化(冰凍)
5）IC：Immunocytochemistry 免疫細(xì)胞化學(xué)