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聯(lián)系我時(shí)，請(qǐng)告知來自 智慧城市網(wǎng)博研生物現(xiàn)貨提供“Anti-ATF1抗體,活化轉(zhuǎn)錄因子1抗體"，產(chǎn)品質(zhì)量保證，提供，有任何質(zhì)量問題可免費(fèi)包退包換，咨詢！
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【產(chǎn)品名稱】：Anti-ATF1抗體,活化轉(zhuǎn)錄因子1抗體（科研）
【產(chǎn)品編號(hào)】：BYK-0517R
【產(chǎn)品規(guī)格】：0.1ml/0.2ml
【產(chǎn)品價(jià)格】：詢價(jià)（電詢或客服）
【抗體來源】：Rabbit OR Mouse or Goat
【產(chǎn)品用途】：科研實(shí)驗(yàn)，用于ELISA實(shí)驗(yàn)、免疫組化實(shí)驗(yàn)，WB實(shí)驗(yàn)，IF實(shí)驗(yàn)等，可，索取產(chǎn)品說明書！
【性 狀】： Lyophilized or Liquid
【濃 度】： 1mg/1ml
【亞 型】： IgG
【貯 存】： 貯存于-20℃.
【相關(guān)標(biāo)記】：HRP Biotin Gold RBITC AP FITC Cy3 Cy5 Cy5.5 Cy7 PE PE-Cy3 PE-CY5 PE-CY5.5 PE-CY7 APC Alexa Fluor 350 Alexa Fluor 488 Alexa Fluor 555 Alexa Fluor 647
【產(chǎn)品別名】：Activating Transcription Factor1; TREB36 protein; ATF 1; ATF1 EWS fusion gene ATF1 FUS fusion gene; cAMP dependent transcription factor 1; Cyclic AMP dependent transcription factor ATF 1; Cyclic AMP dependent transcription factor ATF1; EWS AFT1; FUS ATF 1; RNA binding protein activating transcription factor 1 fusion protein; TREB 36; TREB36; ATF1_HUMAN.
【產(chǎn)品介紹】:ATF1 (Activating Transcription Factor 1, TREB-36) is a member of the ATF/CREB family of basic region leucine-zipper (bZip) DNA-binding proteins that regulates transcription by binding to a consensus cAMP response element (CRE) in the promoter of various viral and cellular genes. Many of these genes are important in cell growth and differentiation, and in stress and immune responses. The activation function of CRE-binding proteins may be modulated by phosphorylation of several kinases and is mediated by coactivators such as CREB-binding protein (CBP) and p300. ATF1 is a nuclear protein that binds DNA as a homodimer or as heterodimers with the inducible transcription factors CREB1 or CREM. Heterodimers appear to be stronger transcriptional activators than the homodimers. Tissue expression of ATF1 mRNA is widespread. Several isoforms of ATF1 arise by differential splicing. ATF1 mediates both Ca2+ and cAMP responses at several levels. It binds to the Tax-responsive element (TRE1) of the human T-cell lymphotropic virus type-I (HTLV1). ATF1 is detectable in metastatic melanoma cells and seems to contribute to their survival. A chimeric protein composed of the N-terminal domain of EWS (Ewing sarcoma oncogene) linked to the bZip domain of ATF1 is implicated in the rare malignant clear cell sarcoma of tendon sheath and aponeuroses (malignant melanoma of soft parts).
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