標(biāo)簽：核苷轉(zhuǎn)運(yùn)蛋白 古朵生物 熒光抗體 ENT1抗體

　　古朵闡述：核苷轉(zhuǎn)運(yùn)蛋白ENT1抗體資料

　　中文名稱 核苷轉(zhuǎn)運(yùn)蛋白ENT1抗體

　　英文名稱 ENT1

　　別 名 Equilibrative NBMPR-sensitive nucleoside transporter; equilibrative nitrobenzylmercaptopurine riboside (NBMPR)-sensitive nucleoside transporter; Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter; Equilibrative nucleoside transporter 1; es-type; MGC1465; MGC3778; Nucleoside transporter; Nucleoside transporter, es-type; OTTHUMP00000016506; OTTHUMP00000016507; OTTHUMP00000016508; OTTHUMP00000016509; OTTHUMP00000016510; OTTHUMP00000016511; OTTHUMP00000016512; S29A1_HUMAN; SLC29A1; solute carrier family 29 (nucleoside transporters), member 1; Solute carrier family 29 member 1.

　　研究領(lǐng)域 腫瘤 細(xì)胞生物 信號轉(zhuǎn)導(dǎo) 新陳代謝

　　抗體來源 Rabbit

　　克隆類型 Polyclonal

　　交叉反應(yīng) Human, Mouse, Rat, Cow, Horse, Sheep, Cynomolgus Monkey, Orangutan

　　產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 核苷轉(zhuǎn)運(yùn)蛋白ENT1抗體(石蠟切片需做抗原修復(fù))

　　not yet tested in other applications.

　　optimal dilutions/concentrations should be determined by the end user.

　　分 子 量 50kDa

　　細(xì)胞定位 細(xì)胞膜

　　性 狀 Lyophilized or Liquid

　　濃 度 1mg/1ml

　　免 疫 原 KLH conjugated synthetic peptide derived from human ENT1/SLC29A1

　　亞 型 IgG

　　純化方法 affinity purified by Protein A

　　儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

　　保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

　　核苷轉(zhuǎn)運(yùn)蛋白ENT1抗體產(chǎn)品介紹 background:

　　Equilibrative nucleoside transporters (ENTs) regulate many physiological processes and are widely distributed in mammals, plants, yeasts, insects, nematodes and protozoans. They enable facilitated diffusion of hydrophilic nucleosides, such as adenosine and nucleoside analogs, across cell membranes. ENTs are required for uptake of antiviral and anticancer nucleoside drugs and influence a variety of physiological processes, such as neurotransmission and platelet aggregation, by regulating the amount of adenoside available to cell surface receptors. Equilibrative nucleoside transporter 1 (ENT1), also designated solute carrier family 29 (nucleoside transporters), member 1, belongs to the SLC29A transporter family and is a mammalian ENT isoform. ENT1, along with ENT3, mediates the majority of influx and efflux of nucleosides across the plasma membrane.

　　Function:

　　Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).

　　Subcellular Location:

　　Basolateral cell membrane. Apical cell membrane. Predominantly localized in the basolateral membrane in polarised MDCK cells.

　　Tissue Specificity:

　　Expressed in heart, brain, mammary gland, erythrocytes and placenta, and also in fetal liver and spleen.

　　Post-translational modifications:

　　Glycosylated.

　　Similarity:

　　Belongs to the SLC29A transporter family.

　　古朵闡述：核苷轉(zhuǎn)運(yùn)蛋白ENT1抗體資料上海古朵生物科技有限公司，由具有資深行業(yè)背景和豐富市場經(jīng)驗(yàn)的專業(yè)人士組成，致力于為生命科學(xué)研究領(lǐng)域提供產(chǎn)品，為廣大科研工作者提供服務(wù)。既能滿足研發(fā)類客戶對產(chǎn)品種類、包裝、純度的特殊要求，也能滿足生產(chǎn)型企業(yè)從小試、中試到規(guī)模化生產(chǎn)各個(gè)階段的綜合需求。產(chǎn)品涵蓋有機(jī)試劑、無機(jī)試劑和生化試劑，標(biāo)準(zhǔn)物質(zhì)、天然植物提取物及中藥標(biāo)準(zhǔn)品，核酸、酶、緩沖劑、顯色底物，醫(yī)藥中間體、原料藥、催化劑、高純?nèi)軇?、特種高分子材料及實(shí)驗(yàn)室常用耗材。品種類超過2萬種，廣泛應(yīng)用于細(xì)胞藥理、藥劑、分子生物學(xué)等科研領(lǐng)域。