Ansamitocin P3通過結(jié)合微管蛋白誘導(dǎo)微管解聚;它具有免疫調(diào)節(jié)和抗癌活性。安薩霉素P3增加T細(xì)胞信號傳導(dǎo)和抗原攝取，并降低體內(nèi)調(diào)節(jié)性T細(xì)胞水平。

艾美捷Ansamitocin P3 #LKT-A5472-5mg相關(guān)信息：

cas#：66547-09-9

純度：≥70%

公式：C32H43CIN2O9

配方重量：635.14

溶解度：10毫米二甲基二甲-基-苯甲酸

儲存溫度：-20°C

Description

Ansamitocin P3 induces microtubule depolymerization by binding tubulin; it exhibits immunomodulatory and anticancer activities. Ansamitocin P3 increases T cell signaling and antigen uptake and decreases regulatory T cell levels in vivo.

Product Info

Cas No. 66547-09-9

Purity ≥70%

Formula C32H43CIN2O9

Formula Wt. 635.14

Solubility 10mM DMSO

Ansamitocin P3文獻(xiàn)參考：

Martin K, Müller P, Schreiner J, et al. The microtubule-depolymerizing agent ansamitocin P3 programs dendritic cells toward enhanced anti-tumor immunity. Cancer Immunol Immunother. 2014 Sep;63(9):925-38. PMID: 24906866.

Venghateri JB, Gupta TK, Verma PJ, et al. Ansamitocin P3 depolymerizes microtubules and induces apoptosis by binding to tubulin at the vinblastine site. PLoS One. 2013 Oct 4;8(10):e75182. PMID: 24124473.