阿達(dá)格拉西布Adagrasib是KRASG12C的抑制劑，KRASG<>C是一種眾-所-周-知的難以治療的癌性突變。

艾美捷 LKT Labs 阿達(dá)格拉西布基礎(chǔ)信息：

編號(hào)：A121008

cas：2326521-71-3

純度：≥99%

公式：C32H35ClFN7O2

配方重量：604.13

IUPAC名稱：2-[（2S）-4-[7-（8-氯萘-1-基）-2-[[（2S）-1-甲基吡咯烷-2-基]甲氧基]-6，8-二氫-5H-吡啶并[3，4-d]嘧啶-4-基]-1-（2-氟丙基-2-烯?；┻?嗪-2-基]乙腈

同義詞：MRTX-849

外觀：白色粉末

阿達(dá)格拉西布文獻(xiàn)參考：

Zhang Y, Li C, Xia C, et al. Adagrasib, a KRAS G12c inhibitor, reverses the multidrug resistance mediated by ABCB1 in vitro and in vivo. Cell Commun Signal. 2022 Sep 14;20(1):142. PMID: 36104708

Sabari J, Velcheti V, Shimizu K, et al. Activity of adagrasib (MRTX849) in brain metastases: preclinical models and clinical data from patients with KRASG12c-mutant non-small cell lung cancer. Clin Cancer Res. 2022 Aug 2;28(15):3318-3328. PMID: 35404402

Koga T, Suda K, Fujino T, et al. KRAS secondary mutations that confer acquired resistance to KRAS G12c inhibitors, sotorasib and adagrasib, and overcoming strategies: insights form in vitro experiments. J Thorac Oncol. 2021 Aug;16(8):1321-1332. PMID: 33971321