FD NeuroSilver™ Kit II is designed for the detection of degenerating neurons in fixed tissue sections of the central nervous system from experimental animals. The principle of this kit is based on the findings that some components of the neurons undergoing degeneration, such as lysosomes, axons, and terminals, become particularly argyrophilic. Under certain conditions, these cellular elements bind to the silver ions with high affinity. Upon reduction, the silver ions form metallic grains that are visible under a light or electron microscope.

FD NeuroSilver™ Kit II has been used widely in animal studies under various experimental conditions. This kit has proven extremely specific and sensitive for the detection of degenerating neuronal somata, axons, and terminals in both the brain and the spinal cord (cf. photo samples). It is particularly useful for the detection of small numbers of degenerating neurons that may not be demonstrable with routine histopathological techniques.

FD NeuroSilver™ Kit II has also been proven to be very sensitive and reliable for the detection of amyloid plaques in the brain of transgenic mice (cf. photo samples). In addition, this kit may be used for demonstrating neurodegeneration and/or amyloid plaques in tissue sections that have been processed for immunohistochemistry (cf. photo samples). The procedure of FD NeuroSilver™ Kit II takes approximately 1 hour.

Kit contents:

Solution A                                      500 ml

Solution B                                      500 ml

Solution C                                      500 ml x 2

Solution D                                      500 ml

Solution E                                       2 ml

Solution F                                       3 ml

Solution G (10X)                             500 ml

Glass Specimen Retriever                2

Natural hair paintbrush                     1

User Manual                                     1

艾美捷FD NeuroTech FD NeuroSilver退化神經(jīng)元銀染試劑盒II（#PK301）設(shè)計(jì)用于檢測(cè)實(shí)驗(yàn)動(dòng)物中樞神經(jīng)系統(tǒng)固定組織切片中的退化神經(jīng)元。該試劑盒的原理是基于以下發(fā)現(xiàn)：經(jīng)歷退化的神經(jīng)元的某些成分，如溶酶體、軸突和末端，變得特別嗜銀。在某些條件下，這些細(xì)胞元素以高親和力與銀離子結(jié)合。還原后，銀離子形成金屬顆粒，在光學(xué)或電子顯微鏡下可見。

FD NeuroSilver退化神經(jīng)元銀染試劑盒II已廣泛用于各種實(shí)驗(yàn)條件下的動(dòng)物研究。該試劑盒已被證明對(duì)檢測(cè)大腦和脊髓中的退化神經(jīng)元體瘤、軸突和末端具有極-高的特異性和靈敏度。它對(duì)于檢測(cè)少量退化神經(jīng)元特別有用，這些神經(jīng)元可能無法通過常規(guī)組織病理學(xué)技術(shù)證明。

FD NeuroSilver退化神經(jīng)元銀染試劑盒II也被證明對(duì)檢測(cè)轉(zhuǎn)基因小鼠大腦中的淀粉樣斑塊非常敏感和可靠（參見照片樣品）。此外，該試劑盒可用于顯示已處理用于免疫組織化學(xué)的組織切片中的神經(jīng)變性和/或淀粉樣斑塊。FD神經(jīng)銀™試劑盒II的過程大約需要1小時(shí)。