囊泡谷氨酸轉(zhuǎn)運體（VGLUTs）包括3個成員，VGLUT1、VGLUT2和VGLUT3。囊泡谷氨酸轉(zhuǎn)運體（VGLUTs）的異常會導致興奮性神經(jīng)遞質(zhì)谷氨酸的異常，從而誘發(fā)多種神經(jīng)系統(tǒng)疾病。

囊泡型谷氨酸轉(zhuǎn)運蛋白1VGLUT1，又稱BNPI和SLc17a7，zui初被鑒定為腦特異性磷酸轉(zhuǎn)運蛋白。與相關(guān)的VGLUT-2一樣，VGLUT-1對谷氨酸的攝取和儲存既是必要的，也是充分的，因此構(gòu)成了谷氨酸能表型的決定因素。這兩種VGLUT都不同于血漿膜轉(zhuǎn)運蛋白，因為它們是由跨囊泡膜的質(zhì)子電化學梯度驅(qū)動的。

VGLUT 1和VGLUT 2呈現(xiàn)互補表達模式?？偠灾?，它們是目前谷氨酸能神經(jīng)末梢和谷氨酸能突觸的標記物。

VGLUT 1 - 135 302，這個來自德國SySy的囊泡谷氨酸轉(zhuǎn)運體1（抗體），特異性針對VGLUT1蛋白（經(jīng)過敲除驗證K.O），作為谷氨酸能神經(jīng)末梢的標記物。（使用說明：VGLUT 1在煮沸后聚集，因此建議對未煮沸的樣品進行SDS-PAGE分析。）

發(fā)表文章超100+：Nature, Cell，課代表~

WB（23+）：

Vesicular Glutamate Transporters (SLCA17 A6, 7, 8) Control Synaptic Phosphate Levels.

Cheret C, Ganzella M, Preobraschenski J, Jahn R, Ahnert-Hilger G

Cell reports (2021) 342: 108623. 135 302 WB, ICC; tested species: human,mouse

IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α.

Tanabe Y, Naito Y, Vasuta C, Lee AK, Soumounou Y, Linhoff MW, Takahashi H

Nature communications (2017) 81: 408. 135 302 WB

IP（2+）：

Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells.

Fasano C, Rocchetti J, Pietrajtis K, Zander JF, Manseau F, Sakae DY, Marcus-Sells M, Ramet L, Morel LJ, Carrel D, Dumas S, et al.

Frontiers in cellular neuroscience (2017) 11: 140. 135 302 WB, IP; tested species: mouse

ICC（33+）：

Neuronal defects in a human cellular model of 22q11.2 deletion syndrome.

Khan TA, Revah O, Gordon A, Yoon SJ, Krawisz AK, Goold C, Sun Y, Kim CH, Tian Y, Li MY, Schaepe JM, et al.

Nature medicine (2020) : . 135 302 ICC; tested species: human

Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program.

Karow M, Camp JG, Falk S, Gerber T, Pataskar A, Gac-Santel M, Kageyama J, Brazovskaja A, Garding A, Fan W, Riedemann T, et al.

Nature neuroscience (2018) : . 135 302 ICC; tested species: human

IHC（40+）：

Context-Specific Striatal Astrocyte Molecular Responses Are Phenotypically Exploitable.

Yu X, Nagai J, Marti-Solano M, Soto JS, Coppola G, Babu MM, Khakh BS

Neuron (2020) : . 135 302 IHC; tested species: mouse

Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue.

Nagai J, Rajbhandari AK, Gangwani MR, Hachisuka A, Coppola G, Masmanidis SC, Fanselow MS, Khakh BS

Cell (2019) : . 135 302 IHC; tested species: mouse

Other（1+）：

Transplantation of neurons derived from human iPS cells cultured on collagen matrix into guinea-pig cochleae.

Ishikawa M, Ohnishi H, Skerleva D, Sakamoto T, Yamamoto N, Hotta A, Ito J, Nakagawa T

Journal of tissue engineering and regenerative medicine (2017) 116: 1766-1778. 135 302

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文章來源：艾美捷科技