Rabbit anti-BAX
Catalog Number : HZ94291 Quantity size : 0.1ml (dilute with pH 7.4 0.01 M PBS or antibody diluent )
Background: The Bcl-2 gene was isolated at the chromosomal breakpoint of t(14;18)-bearing follicular B cell lymphomas(1,2).Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal (3,5).Bcl-2 appears to function in several subcellular locations yet lacks any known motifs that would confer insight into its mechanism of action (6,7).A more recently identified protein,designated Bax p21(i.e., Bcl-associated X protein ),has extensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2(8).Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line and Bax also counters the death repressor activty of Bcl-2(8).
Specificity :
- anti- BAX is a rabbit polyclonal antibody unconjugated
- specific for BAX of human, rat, bovine, sheep, dog, pig,mouse
- broadly reactive with mammalian species
- epitope mapping near the am ino terminus of BAX of human, mo, rat, bovine, sheep, dog, pig origin
- use for western blotting, e lisa, immunoprecipitation and immunohistochemistry
- Protein G affinity chromatogr aphy purification,Purity>95%
- Isotype: IgG
- mol wt: 26 kDa
Storage: Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody, the antibody is stable for at least six weeks at 2-4 ℃.
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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