Mouse Anti-HERPUD1 抗體說明書
Quantity size : 100ug (dilute with pH 7.4 0.01 M PBS or antibody diluent )
Backgroud: HERPUD1 is a includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined. [provided by RefSeq, Jan 2013]. Function : Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradationofmisfolded endoplasmic reticulum proteins. Could enhancepresenilin-mediatebeta-amyloid protein 40 generation.Subunit : Interacts with PSEN1 and PSEN2. Interacts with SYVN1 and UBXN6.Subcellular Location : Endoplasmic reticulum membrane; Multi-pass membrane protein.Tissue Specificity : Widely expressed; in the brain, expression seems to be restricted to neurons and vascular smooth muscle cells. Anti-HERPUD1 抗體說明書
Specificity : Anti- HERPUD1is a Mouse Monoclonal antibody
specific for HERPUD1 of Rat,Human
- use for western blotting,elisa,immunoprecipitation and immunohistochemistry
- Protein G affinity chromatography purification, purity :>95%
- Isotype: IgG
- mol wt: 44kDa Anti-HERPUD1 抗體說明書
Application :
- Flow-cyt=1:50-200
- WB=1:100-500
- ELISA=1:500-1000
- IP=1:20-100
- IHC-P=1:100-500
- IHC-F=1:100-500
- IF=1:100-500
- optimal dilutions/concentrations should be determined by the end user..
Storage: Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody, the antibody is stable for at least six weeks at 2-4 ℃
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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